ProductsAbout MCRF

Substances discovered by the MCRF and launched

	Substance (Brand name)	Use	Discovered	Marketed
1.	Kanamycin	Antibacterial chemotherapeutic drug	1957	1958
2.	Bekanamycin (Kanendomycin)	Antibacterial chemotherapeutic drug	1957	1969
3.	Bleomycin (Bleo)	Anti-cancer chemotherapeutic drug	1965	1969
4.	Kasugamycin (Kasumin)	Agrochemical for rice blast disease	1965	1970
5.	Josamycin	Antibacterial chemotherapeutic drug	1967	1970
6.	Dibekacin (Panimycin)	Antibacterial chemotherapeutic drug	1971	1975
7.	Peplomycin (Pepleo)	Anti-cancer chemotherapeutic drug	1977	1981
8.	Aclarubicin (Aclacinon)	Anti-cancer chemotherapeutic drug	1975	1982
9.	Ubenimex (Bestatin)	Anti-cancer chemotherapeutic drug	1976	1987
10.	Prarubicin (Pinorubin, Therarubicin)	Anti-cancer chemotherapeutic drug	1979	1988
11.	Tylvalosin (Aivlosin)	Antibacterial veterinary drug	1979	1989
12.	Arbekacin (Habekacin)	Antibacterial chemotherapeutic drug	1973	1990
13.	Gusperimus (Spanidin)	Immunosuppressive agent	1982	1994
14.	Tildipirosin (Zuprevo)	Antibacterial veterinary drug	2000	2011

Commercially available enzyme inhibitors used as reagents

	Substance	Enzyme inhibitor	Discovered in
1.	Leupeptin	Serine/Cysteine proteinase	1969
2.	Pepstatin	Aspartic proteinase	1970
3.	Chymostatin	Serine/Cysteine proteinase	1970
4.	Antipain	Serine/Cysteine proteinase	1972
5.	Phosphoramidon	Metalloproteinase	1973
6.	Elastatinal	Serine proteinase	1973
7.	Amastatin	Aminopeptidase	1978
8.	Ebelacton	Esterase, Lipase, Aminopeptidase	1980
9.	Arphamenines	Aminopeptidase	1983
10.	Diprotin A	Dipeptidylaminopeptidase	1984
11.	Actinonin	Aminopeptidase	1985
12.	Foroxymithine	Dipeptidylaminopeptidase	1985
13.	Leuhistin	Aminopeptidase	1990
14.	Cytostatin	Protein phosphatase 2A	1994
15.	Heliquinomycin	DNA helicase	1996
16.	Rubratoxin A	Protein phosphatase 2A	2010 (Activity)
17.	Heparastatin (SF4)	Heparanase	1994