化合物一覧

Heparastatin (SF4)

Producing organism:

-

Activity:

Heparanase inhibitor

Clinical use:

-

Class no:

-

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Title Author Journal Year Volume Page
Effect on spontaneous metastasis of mouse Lewis lung carcinoma by a trifluoroacetamide analogue of siastatin B. Nishimura Y, Satoh T, Kondo S, Takeuchi T, Azetaka M, Fukuyasu H, Iizuka Y, Shibahara S J. Antibiotics 1994 47 840-842
A practical synthesis of (3S,4S,5R,6R)-4,5-dihydroxy-6-(trifluoroacetamido)piperidine-3-carboxylic acid having antimetastatic activity in mice from siastatin B. Satoh T., Nishimura Y., Kondo S., Takeuchi T. Carbohyd. Res 1996 286 173-178
Flexible synthesis and biological activity of uronic acid-type gem-diamine 1-N-iminosugars: a new family of glycosidase inhibitors. Nishimura Y, Shitara E, Adachi H, Toyoshima M, Nakajima M, Okami Y, Takeuchi T Org. Chem. 2000 65 2-11
Heparanase regulates esophageal keratinocyte differentiation through nuclear translocation and heparin sulfate cleavage. Kobayashi M., Naomoto Y., Nobuhisa T., Okawa T., Takaoka M., Shirakawa Y., Yamatsuji T., Matsuoka J., Mizushima T., Matsuura H., Nakajima M., Nakagawa H., Rustgi A., Tanaka N Differentiation 2006 74 235-243
Involvement of heparanase in migration of microglial cells. Takahashi H., Matsumoto H., Smirkin A., Itai T., Nishimura Y., Tanaka J., Biochim. Biophys. Acta. 2008 1780 709-715
Heparanase downmodulation in the process of epithelial-to-mesenchymal transition of mouse mammary epithelial cells. Kogane Y., Higashi N., Nishimura Y., Nakajima M., T.Irimura T J. Glycomics Lipdomics 2013 3 107